Once the heart and brain have gone without oxygen for a while, naloxone will not work. This is why it is so important to administer naloxone as soon as possible. While using fentanyl, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs.
Overdose Prevention

He decided to seek out something that would be both safer and cheaper. For the past three years, he’s been buying fentanyl and its analogues, like carfentanil, online. When he receives it, he measures it out in water, which he says makes for greater accuracy. Now, for that amount, he can get enough fentanyl to last more than three weeks. The drug user in Texas said he first began using opioids when a doctor prescribed him hydrocodone for a bad cough he had as a teenager. He progressed to prescription painkillers, and then, when they became too expensive, to heroin.
Become A Harm Reduction Champion
Illicit fentanyl related products are described including the different forms it can appear in. The rise in use and overdoses are described as well as some of the reasons for these changes. Implications for overdose prevention and initiating treatment with medications for opioid use disorder are described.

Dispose of unneeded tablets by removing them from the packaging and flushing them down the toilet. Throw the remaining fentanyl packaging or cartons into a trash container; do not flush these items down the toilet. Call your pharmacist or the manufacturer if you have questions or need help disposing of unneeded medication. Do not stop using fentanyl without talking to your doctor. If you suddenly stop using fentanyl, you may experience unpleasant withdrawal symptoms.
Fentanyl Overdose
42% of pills tested by the DEA for fentanyl contained at least 2 mg of fentanyl, considered a potentially lethal dose. An estimated 10 million doses of controlled substances have … Fentanyl overdoses are more common and deadlier than other o… If a patient is taking this drug on a prescription basis, they need to communicate immediately with their physician if they experience any adverse effects. As these are unofficial terms, they can rapidly change and vary from region to region. Healthcare providers, law enforcement, and the public should stay aware of these changes.
If you choose to use fentanyl, there are some practices that can help you minimize the risk of an overdose. Here are a few recommendations so you can be in control of your experience. Fentanyl is a strong synthetic opioid that has been used in clinical settings since 1968. Fentanyl can be made into pills or powders, which can unknowingly get mixed into other drugs. A 26-year-old man with a history of fentanyl abuse was found unresponsive in a gas station bathroom.
- Using a drug that has been contaminated with or replaced by fentanyl can greatly increase the risk of a life-threatening overdose.
- Fentanyl is a naturally occurring substance in the human body known for its calming and euphoric effects.
- It’s hard to predict the amount of fentanyl that could kill someone.
- This percentage may be even higher as fentanyl can easily be mixed with other drugs, often without the user’s knowledge, which has made it particularly dangerous.
OUDs are chronic but treatable medical conditions that involve changes in our brains, which makes stopping very difficult without support. Effective medications that address cravings and withdrawal symptoms, as well as behavioral treatments, can help people with OUDs. From April 2024 to March 2025, the CDC reported 43,000 synthetic opioid deaths, most of which are from fentanyl, down from nearly 70,000 in the previous similar period.

National Coalition Against Prescription Drug Abuse
Fentanyl, regardless of its form, is extremely potent and dangerous. Just two milligrams of fentanyl can be fatal for the average person. When fentanyl is mixed into other drugs, it cannot be seen, smelled, or tasted, and it’s nearly impossible to distinguish counterfeit pills containing fentanyl from legitimate ones. Fentanyl is extremely potent and is considered to be up to 100 times stronger than morphine and 50 times stronger than heroin. A single dose of fentanyl is considered to be 100 mcg-400 mcg and can cost around $2 or less on average in 2025, depending on the location of sale, what the fentanyl is cut with, and other factors. Typically, prescription drugs sold on the street are not sold in increments this small.
How Does Fentanyl Make People Feel?
If you test one pill from a bottle or bag of pills, that one dose might not have fentanyl in it, but the others might. Two important harm reduction tools are the medication naloxone (also known by its brand name Narcan) and fentanyl test strips. Always prioritize your health and safety, and do not hesitate to reach out for help if you are dealing with fentanyl addiction or other substance use issues. Contact a treatment provider today to learn more about your treatment options. People taking a daily prescribed dose will become dependent on the drug and will have withdrawal symptoms if they stop it.

How Do You Find The Right Drug Treatment
Deaths from fentanyl — the synthetic, often deadly opioid frequently present in illicit street drugs — have contributed to the United States’ soaring opioid overdose deaths in the last decade. “In health care, we dose fentanyl in micrograms,” explains Amanda N. Donald, MD, an addiction medicine physician at Northwestern Medicine. The medication will reverse the effects of fentanyl and block future effects.
What Are The Signs Of A Fentanyl Overdose?
We receive compensation from Treatment X in exchange for ad placement. This advertisement is clearly marked and is separate from our editorial content. Someone will go to take their “regular dose” and not realize they are taking something much, much stronger.
In high enough doses, opioids can cause breathing to stop completely. Fentanyl’s strength increases this risk of overdose substantially. Synthetic opioids sold illicitly can be mixed with heroin or cocaine, which amplifies its potency and potential danger. This is particularly dangerous if an individual who uses illegal substances like heroin or intentionally misuses prescription drugs is unaware that fentanyl could be in it. Prescription fentanyl is FDA -approved to treat severe pain related to surgery or complex pain conditions. Over the past decade, fentanyl that is made and distributed illegally has become increasingly common in the illegal drug supply and has contributed to a surge in drug overdose deaths.
Naloxone can reverse a fentanyl overdose, although in some cases it may take more doses because fentanyl is so potent. You should also call 911, just like for any medical emergency, so extra help is on the way. One measure to prevent fentanyl overdose is distributing naloxone to bystanders. Naloxone can reverse an overdose as it occurs by blocking the effects of opioids. Even if you don’t use opiates, or any drugs at all, you probably know someone who has been affected by addiction and overdose deaths.
When it is intentionally misused, fentanyl often shows up as a powder, spiked on blotter paper or is mixed with or substituted for heroin and other street drugs. First responders will likely administer naloxone if you haven’t already, or give it to them again. Naloxone only works in the body for 30 to 90 minutes, so it’s possible for someone to still have overdose effects after the medication wears off or needs multiple doses. Dealers may sell it as a standalone drug or as a counterfeit for another drug (like oxycodone). It’s also used as a low-cost additive to other drugs like heroin, methamphetamine, molly, and ecstasy. This overdose rate has continued to rise in part because fentanyl is often mixed into or sold as other drugs.
Fentanyl is a powerful opioid pain medication as well as a common contaminant found in illicit drugs. The antidote naloxone (Narcan) can reverse the effects of a fentanyl overdose if given in time. To put it in perspective, it’s 50 to 100 times more potent than morphine.